Copper-Catalyzed Amidation of Aryl Iodides Using KF/Al₂O₃: An Improved Protocol

Abstract

A mild method for the copper-catalyzed amidation of aryl iodides is reported. This simple C-N bond forming procedure shows that the combination of air stable CuI and 1,10-phenanthroline in the presence of KF/Al₂O₃ comprises an extremely efficient and general catalyst system for the N-amidation of aryl iodides. Different functionalized aryl iodides were efficiently coupled with amides using this method.

amidation - aryl iodides - copper iodide - potassium ­fluoride on alumina - coupling reaction

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